Alpine Dispensary’s Sleep Support gummies combine Cannabidiol (CBD), Cannabinol (CBN), Passion Flower, Lemon Balm and Chamomile to create a solution for sleep issues. I wrote about stacking compounds in one of my earlier blogs. The concept of stacking compounds entails combining several substances with similar or complimentary effects to get maximum desired results. In the case of Alpine Dispensary’s Sleep Support gummies, the CBD serves as a metabolic catalyst for the other compounds which are sedatives. There are literally thousands of anecdotal testimonies to the anti-inflammatory, anti-anxiolytic and neuroprotective benefits of CBD. CBD also helps the body use other substances more efficiently. People are familiar with CBD and it has been widely studied at this point, but CBN, the other cannabinoid in our sleep support gummies, is not as widely known.
Cannabinol (CBN), rapidly became popular and was immediately embraced as a sedative. In a backwards way the science was ahead of the curve on this one. Through testing for potency in medical markets it was discovered that levels of THC ∆9 go down and levels of CBN go up as cannabis plants age and decompose after harvest. The conclusion reached was that THC ∆9 degrades into CBN. When this news reached the cannabis community, potheads recalled teenage memories of old brick weed that when smoked left them heavy bodied, red-eyed, hungry and laid out on the couch for extended periods of time. The industry went crazy for a time proclaiming that CBN will be the sleep remedy that replaces all others. It turns out studies on CBN as an isolated compound don’t show conclusive results one way or another. What the studies do show is that the sedative effects of CBN are a lot like they are with other cannabinoids. It is relative to the amount you take and the other substances that are present. Also, CBN doesn’t have to come from THC ∆9; it can come from CBD as well, you just have to wait a little longer.
It is now common knowledge that the Endocannabinoid System (ECS) is the primary way for most cannabinoids to initiate changes in your body. CBD and CBN both use this system to reduce pain, inflammation and protect your nerves. CBD reacts with the ECS in a completely unique way. CBN uses the system by binding to the CB1 and CB2 receptors like the various forms of THC. CBN binds a little bit better to the CB2 receptor than it does to the CB1. We know that the CB2 receptors primarily deal with your immune system and metabolic processes. A paper from the British Journal of Pharmocology explains how cannabinoids also use the Transient Receptor Potential (TRP) channels either through the ECS response or directly by binding with receptors in the channels (1). With cannabinoids like CBD and CBN, there are effects that take time to manifest. The neurochemicals that regulate sleep and wakefulness, melatonin and seratonin, are partially regulated through these same channels and the ECS. Sustained dalily use of CBD and CBN will help these systems balance out over time. Your body and mind will naturally reach equilibrium and get maximum benefit out of the sleep that you do manage to find time for. What CBD and CBN will do is make the other sedative compounds in Alpine Dispensary’s Sleep Support gummies work better to provide you with a refreshing nights sleep.
The three herbs that are in Alpine Dispensary’s Sleep gummies are Passion flower, Lemon Balm, and Chamomile. Plenty of studies have been done on each of these herbs to verify their sedative properties. I picked out some of the studies I found and included links so that you can read up on each of these powerful plants.
One of the most widely known homeopathic remedies for a lot of different ailments is chamomile. An article entitled Chamomile an Herbal Medicine of the Past with a Bright Future from Molecular Medicine Reports in 2010 states:
“The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and hemorrhoids.” (2)
As you can see by this quote, chamomile does more than function as a sleep aid. It also points to something not so easily seen. It is a combination of all the different compounds in chamomile that get all of these different results. One thing that I have garnered from doing all of this research on cannabis, is that whole plant medicine is best just like it is with herbal medicine.
Passionflower, more commonly known to us in Southern Appalachia as a maypop, is a beautiful complex flower. The vine does produce an edible fruit but it is more commonly known for the narcotic, sedative properties of the dried flower. In the 2017 July issue of Sleep Science Journal, Guerrero and Medina reported on the sedative effects of Passionflower. There research showed:
“Passiflora incarnata induced a significant increment in the total sleep time. This increment was due to an increase in the time spent by animals in slow wave sleep (SWS). Concomitantly, a significant decrement in wakefulness (W) was observed (p<0.05). In contrast, time spent in rapid eye movement (REM) sleep showed a decreasing tendency, since both its frequency and mean duration were reduced… The extracts obtained from Passiflora incarnata can be considered as appropriated sleep inducers.” (3)
Basically, this says that passion flower does two things in regards to sleep. It reduces the time that we stay in the lighter stages of sleep and increases the amount of time that we are in deep sleep. Passionflower has been most closely linked to hypnotic drugs. This compound has the potential to help you stay asleep and remain deep enough in that sleep so any noise or other distractions will not wake you up.
Lemon Balm, the third herb in Alpine Dispensary’s Sleep Support gummies, is not quite as widely known in the Western hemisphere as chamomile and passion flower. However, lemon balm is widely known in the Eastern Hemisphere. In the Journal of Evidence Based Complimentary and Alternative Medicine a team of scientists led by Miraj Sipede reviewed Melissa Officinalis aka Lemon Balm. Their findings revealed that lemon balm has been used for the following conditions:
“Historically lemon balm has been said to possess sedative/tranquilizing, anti-gas, fever-reducing, antibacterial, spasmolytic, hypotensive, memory-enhancing, menstrual- inducing, and thyroid-related effects; antiviral and antioxidant activities; antifungal, antiparasitic, and antispasmolytic activities; flatulence; asthma; bronchitis; amenorrhea; cardiac failure; arrhythmias; ulcers; and wounds. Besides, it has been said that it is effective in treatment of headaches, indigestion, colic, nausea, nervousness, anemia, vertigo, syncope, malaise, insomnia, epilepsy, depression, psychosis, and hysteria.” (4)
The team of scientist tested these potentialities and discovered evidence for some, but not all. Insomnia was one of the conditions that is relieved by lemon balm. It is also an anti-anxiolytic, anti-inflammatory and it can settle digestive issues. These same properties are shared by CBD. CBD will also help lemon balm work better in the same way it will for passion flower, chamomile and CBN. Stacking similar compounds for a singular goal delivers maximum results.
Alpine Dispensary’s Sleep Support gummies will provide the good nights sleep you deserve. The sedative compounds found in lemon balm, passion flower, and chamomile are turbocharged by the metabolic enhancing properties of CBD and CBN. They work so well in fact that some people should cut them in half. If you have any questions on our new Sleep Support gummies visit one of our two Helen Georgia locations, call us during store hours at 1-855-420-HEMP, or follow us on your favorite social media platform.
J.C. Dyer, Mojo Coordinator
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- De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011 Aug;163(7):1479-94. doi: 10.1111/j.1476-5381.2010.01166.x. PMID: 21175579; PMCID: PMC3165957. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165957/
2. Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright
future. Mol Med Rep. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377. PMID:
21132119; PMCID: PMC2995283.
3. Guerrero FA, Medina GM. Effect of a medicinal plant (Passiflora incarnata L) on sleep. Sleep
Sci. 2017 Jul-Sep;10(3):96-100. doi: 10.5935/1984-0063.20170018. PMID: 29410738;
PMCID: PMC5699852. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699852/
4. Miraj S, Rafieian-Kopaei, Kiani S. Melissa officinalis L: A Review Study With an Antioxidant
Prospective. J Evid Based Complementary Altern Med. 2017 Jul;22(3):385-394. doi:
10.1177/2156587216663433. Epub 2016 Sep 11. PMID: 27620926; PMCID: PMC5871149.